USA Only. We cannot order testing in NY, and some labs will not allow ordering in NJ or RI.
USA Only. We cannot order testing in NY, and some labs will not allow ordering in NJ or RI.

Total Tox Burden + Organic Acids

Test Category: Tag

Know what toxins are compromising your body’s ability to be healthy and vital and identify conditions associated with genetic disorders, nutrient deficiencies, intestinal dysbiosis, and toxicity from diet and prescription drugs


The Total Tox-burden is a simple and quick test that provides comprehensive insight on the levels of heavy metals, mold toxins, and environmental toxins in your body. Adding the Organic Acids tests provides an evaluation of intestinal microbial overgrowth, detoxification, mitochondrial markers, neurotransmitter metabolism, glutathione status, fatty acid metabolism, and inborn errors of metabolism.


The Total Tox-burden includes measurements of 20 heavy metals, 31 mycotoxins, and 39 environmental toxins along with 75 organic acids. Knowing your total toxin burden is the first step to removing those toxins and feeling better. Adding the Organic Acids test can provide great insights in discovering underlying causes of chronic symptoms.

Symptoms and risk factors

  • Fatigue (sluggish, tired)
  • Swelling/burning lips/tongue
  • Dry cough
  • Wheezing
  • Shortness of breath
  • Irregular heartbeat
  • Stiff joints
  • Stiff muscles
  • Mood swings (rapid changes)
  • Rashes or hives
  • Daytime sleepiness
  • Insomnia at night
  • Forgetfulness
  • Lack of concentration/Brain fog
  • Itchy skin
  • Increased urinary frequency
  • Stomach pains/cramps
  • Intestinal pains/cramps
  • Bloating sensation
  • Diarrhoea

Is this test right for me?

If you’ve tried diet and exercise but still can’t reach your goals, toxins may be getting in the way! This test trio provides the most comprehensive insight into your total toxin burden and underlying causes of chronic symptoms.

How accurate is this test?

The Vibrant Total Tox Burden panel uses the most advanced method to measure 89 different markers to assess toxic burden in one simple urine specimen.

How should I prepare for this test?

Fasting is not required for the Heavy Metals, Environmental Toxins, or Mycotoxins tests. However, fasting for 12 hours may increase the amount of toxins excreted in urine, so consult with your ordering provider about whether they recommend you fast for 12 hours before the test.

Some Vibrant America ordering providers may prefer you do a “provoked” test which requires taking a “provoking agent” (such as NAC, glutathione, DMSA, or EDTA) prior to testing to promote the release of body stores of metals so that the metals are “mobilized” (moved through the body) and excreted (released) in urine. Vibrant America does not require a provoked test, nor does Vibrant America recommend a specific provoking agent, dose, or
timing of provocation before testing. Discuss with your ordering provider whether they recommend a provoked or unprovoked test, and which provoking agent, dose, and timing of provocation and urine collection they recommend for you. Please note that unprovoked test results cannot predict provoked test results as the absorption, distribution, metabolism, and excretion (release) of heavy metals in urine is highly variable in different people and is influenced by a number of physical, dietary, and environmental factors. Overall, the majority of Vibrant America ordering providers order unprovoked testing.

Avoid foods high in iodine (seafood, dairy, seaweed) and selenium (Brazil nuts) as they have a strong binding affinity for heavy metals (they act like “heavy metal magnets”). Consuming these foods prior to the Heavy Metals test may cause falsely lowered results.

Avoid apples, grapes, pears, and cranberries as well as their juices or products, mushrooms, and ribose supplements 48 hours before collecting for the Organic Acids tests.

For best test performance, collect the first morning urine upon awakening, prior to eating or drinking.

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